IMPURITIES

Bortezomib 1R, 2R Isomer is a Impurity of Bortezomib with CAS Registry No: 1132709-15-9
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CAT No. CS-O-31035
Category Impurities
Parent API Bortezomib
CAS 1132709-15-9
Mol. Weight 384.24 g/mol
Mol. Formula C₁₉H₂₅BN₄O₄

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More info about Bortezomib 1R, 2R Isomer
Synonyms Bortezomib 1R, 2R Isomer;[(1R)-3-methyl-1-[(2R)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid;B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid
Storage Conditions Store at refrigerator (2-8°C) for long term storage
Purity (%) 98.58
Application Notes (1R,2R)-Bortezomib is a diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)
The balance used are calibrated with weights Traceable to National Standards NIST for accuracy



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